PUS1 Antikörper (AA 377-427)

Produktnummer ABIN7454768

Dieses Anti-PUS1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von PUS1 in WB, IP und IHC (fp). Geeignet für Human.

Kurzübersicht für PUS1 Antikörper (AA 377-427) (ABIN7454768)

Target: PUS1 (Pseudouridylate Synthase 1 (PUS1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PUS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Produktdetails anti-PUS1 Antikörper

Bindungsspezifität: AA 377-427

Verwendungszweck: Rabbit anti-PUS1 Antibody, Affinity Purified

Aufreinigung: Affinity Purified

Immunogen: between AA 377 and 427

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu PUS1

Target: PUS1 (Pseudouridylate Synthase 1 (PUS1))

Andere Bezeichnung: PUS1

Hintergrund: Background: Pus1 (pseudouridylate synthase 1) is an enzyme that converts uridine to pseudouridine in non-coding RNA substrates. Pus1 modifies uridines at specific positions in a subset of tRNAs. Pseudouridylation is known to affect the structure of tRNAs and stabilize base-stacking and base-pairing in the anticodon loop. Pus1 activity is important for proper folding and function of tRNAs. Pus1 has also been shown to pseudouridylate SRA (steroid receptor RNA activator) and function as a coactivator. Defects in pseudouridylation are associated with the human disease, MLASA (myopathy with lactic acidosis and sideroblastic anemia), an autosomal recessive oxidative phosphorylataion disorder specific to skeletal muscle and bone marrow.

Gen-ID: 80324

NCBI Accession: NP_079491

UniProt: Q9Y606