FKBP5 Antikörper (AA 407-457)

Produktnummer ABIN7454751

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch FKBP5 in WB, IP und IHC (fp). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für FKBP5 Antikörper (AA 407-457) (ABIN7454751)

Target: FKBP5 (FK506 Binding Protein 5 (FKBP5))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FKBP5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Produktdetails anti-FKBP5 Antikörper

Bindungsspezifität: AA 407-457

Verwendungszweck: Rabbit anti-FKBP5/FKBP51 Antibody, Affinity Purified

Homologie: Orangutan

Aufreinigung: Affinity Purified

Immunogen: between AA 407 and 457

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IHC: 1:200 - 1:1,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu FKBP5

Target: FKBP5 (FK506 Binding Protein 5 (FKBP5))

Andere Bezeichnung: FKBP5/FKBP51

Hintergrund: Background: FKBP5/FKBP51 is an immunophilin and target of FK506, a macrolide immunosuppressive drug derived from Streptomyces tsukubaensis. Like other FK506 binding proteins, FKBP5/FKBP51 exhibits peptidyl-prolyl cis-trans isomerase activity. The most studied role of FKBP5/FKBP51 surrounds its involvement in the regulation of steroid receptor signaling. In association with the molecular chaperones Hsp90 and Hsp70, FKBP5/FKBP51 is able to influence steroid-hormone binding affinity and transcriptional activity. Recently, FKBP5/FKBP51 has become of interest in the field of psychiatry due to its potential role in cortisol regulation and its relation to mood disorders.

Gen-ID: 2289

NCBI Accession: NP_004108

UniProt: Q13451