AKAP8 Antikörper (C-Term)

Produktnummer ABIN7454715

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch AKAP8 in WB, IP und IHC (fp). Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für AKAP8 Antikörper (C-Term) (ABIN7454715)

Target: AKAP8 (A Kinase (PRKA) Anchor Protein 8 (AKAP8))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AKAP8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Produktdetails anti-AKAP8 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: Rabbit anti-AKAP8/AKAP95 Antibody, Affinity Purified

Aufreinigung: Affinity Purified

Immunogen: between AA 642 and C-term

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IHC: 1:200 - 1:1,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu AKAP8

Target: AKAP8 (A Kinase (PRKA) Anchor Protein 8 (AKAP8))

Andere Bezeichnung: AKAP8/AKAP95

Hintergrund: Background: AKAP8/AKAP95 has been characterized as a 95 kDa protein kinase A (PKA)-anchoring protein and regulatory subunit of PKA that functions to recruit the condensin complex for chromosome condensation during mitosis. A role in DNA replication has also been demonstrated through its interaction with the pre-replication complex component, MCM2 (mini-chromosome maintenance 2). Inhibition of AKAP8/AKAP95 association with MCM2 inhibits replication initiation and elongation in vitro. AKAP8/AKAP95 has also been shown to be involved in apoptosis. KAP8/AKAP95 associates with caspase 3 and serves as a carrier to transport caspase 3 from the cytoplasm to the nucleus to induce morphological changes in the nucleus.

Gen-ID: 10270

NCBI Accession: NP_005849

UniProt: O43823

Pathways: SARS-CoV-2 Protein Interaktom