KIF2C Antikörper (AA 50-100)

Produktnummer ABIN7454690

Dieses Anti-KIF2C-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von KIF2C in WB, IP und IHC (fp). Geeignet für Maus.

Kurzübersicht für KIF2C Antikörper (AA 50-100) (ABIN7454690)

Target: KIF2C (Kinesin Family Member 2C (KIF2C))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KIF2C Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Produktdetails anti-KIF2C Antikörper

Bindungsspezifität: AA 50-100

Verwendungszweck: Rabbit anti-MCAK Antibody, Affinity Purified

Homologie: Rat

Aufreinigung: Affinity Purified

Immunogen: between AA 50 and 100

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IHC: 1:500 - 1:2,000. Epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate. A300-921A is less efficient at IP than is A300-922A.

WB: 1:2,000 - 1:10,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu KIF2C

Target: KIF2C (Kinesin Family Member 2C (KIF2C))

Andere Bezeichnung: MCAK

Hintergrund: Background: Kinesin activity has been linked to various cellular functions such as vesicle transport, mitotic spindle formation, chromosome segregation, chromosome congression, and cytokinesis. Structurally, all kinesins contain a motor domain with microtubule and nucleotide binding sites that utilize ATP to target cargo along microtubule filaments. MCAK (Mitotic Centromere-Associated Kinesin) is the founding member of kinesin-13 proteins. There are 3 independent genes coding for kinesin-13 proteins kif2a, kif2b, and kif2c (MCAK). Instead of functioning as a translocator of microtubules MCAK is a depolymerizer that is primarily responsible for releasing improper microtubule-kinetochore attachments during cell division.

Gen-ID: 73804

NCBI Accession: NP_608301

UniProt: Q922S8

Pathways: Microtubule Dynamics