CARM1 Antikörper (C-Term)

Produktnummer ABIN7454627

Der Kaninchen Polyklonal anti-CARM1 Antikörper (ABIN7454627) detektiert spezifisch CARM1 in WB, IP und IHC (fp). Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für CARM1 Antikörper (C-Term) (ABIN7454627)

Target: CARM1 (Coactivator-Associated Arginine Methyltransferase 1 (CARM1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CARM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Produktdetails anti-CARM1 Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: Rabbit anti-CARM1 Antibody, Affinity Purified

Homologie: Rat

Aufreinigung: Affinity Purified

Immunogen: Between AA 550 and C-term

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IHC: 1:500 to 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: 1:10,000 - 1:25,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu CARM1

Target: CARM1 (Coactivator-Associated Arginine Methyltransferase 1 (CARM1))

Andere Bezeichnung: CARM1

Hintergrund: Background: Protein arginine methylation is a form of post-translational modification that is catalyzed by protein arginine methyltransferases (PRMTs). CARM1 (coactivator-associated arginine methyltransferase 1), also known as PRMT4, has been shown to interact with and methylate RNA splicing factors such as CA150 that link transcription to splicing. In this context, CARM1 may be involved in spinal muscular atrophy pathogenesis. CARM1 has also been found to be a coactivator of the NFKappaB transcription factor and the androgen receptor.

Gen-ID: 10498

NCBI Accession: NP_954592

UniProt: Q86X55

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Positive Regulation of fat Cell Differentiation