THO Complex 4 Antikörper (AA 75-125)

Produktnummer ABIN7454474

Dieses Anti-THO Complex 4-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von THO Complex 4 in IP und IHC (fp). Geeignet für Human.

Kurzübersicht für THO Complex 4 Antikörper (AA 75-125) (ABIN7454474)

Target: THO Complex 4 (THOC4)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser THO Complex 4 Antikörper ist unkonjugiert

Applikation: Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Produktdetails anti-THO Complex 4 Antikörper

Bindungsspezifität: AA 75-125

Verwendungszweck: Rabbit anti-Aly Antibody, Affinity Purified

Homologie: Mouse,X. laevis,X. tropicalis,Bovine

Aufreinigung: Affinity Purified

Immunogen: between AA 75 and 125

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

WB: Not recommended

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu THO Complex 4

Target: THO Complex 4 (THOC4)

Andere Bezeichnung: Aly

Hintergrund: Background: Aly (ally of AML-1 and LEF-1) is a component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. Aly also functions as a chaperone and promotes the dimerization of transcription factors containing basic leucine zipper (bZIP) domains and thereby promotes transcriptional activation. Additionally, Aly plays a role in mRNA processing and export and may function as scaffold that mediates interactions between proteins and/or RNA. Aly is also part of the exon junction complex that remains associated with spliced mRNA and plays an important role in mRNA export and nonsense-mediated RNA decay. Aly directs mRNA derived from Herpes simplex virus intron-less genes to the NXF1-mediated export pathway [taken from the Universal Protein Resource (UniProt) Q886V81].

Gen-ID: 10189

UniProt: Q86V81