ZEB2 Antikörper (AA 750-800)
Kurzübersicht für ZEB2 Antikörper (AA 750-800) (ABIN7454452)
Target
Alle ZEB2 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 750-800
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Verwendungszweck
- Rabbit anti-ZEB2/SIP Antibody, Affinity Purified
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Aufreinigung
- Affinity Purified
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Immunogen
- between AA 750 and 800
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Isotyp
- IgG
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Applikationshinweise
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IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
IP: 2 - 5 μg/mg lysate
WB: Not recommended. Use rabbit anti-ZEB2/SIP antibody A302-474A.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 1000 μg/mL
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Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C
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Haltbarkeit
- 12 months
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- ZEB2 (Zinc Finger E-Box Binding Homeobox 2 (ZEB2))
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Andere Bezeichnung
- ZEB2/SIP
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Hintergrund
- Background: Smad interacting protein 1 (SIP1) is a transcriptional inhibitor that binds to the DNA sequence, 5'-CACCT-3', in different promoters. SIP1 has been shown to repress the transcription of E-cadherin. Defects in the gene which encodes for SIP1, ZEB2, are the cause of Hirschsprung disease-mental retardation syndrome (Hirschsprung disease) also known as Mowat-Wilson syndrome (MWS). Hirschsprung disease is a rare autosomal dominant complex developmental disorder [taken from the Universal Protein Resource (UniProt) O60315].
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Gen-ID
- 9839
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NCBI Accession
- NP_055610
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UniProt
- O60315
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Pathways
- Tube Formation
Target
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