DGCR8 Antikörper (AA 400-450)
Kurzübersicht für DGCR8 Antikörper (AA 400-450) (ABIN7454450)
Target
Alle DGCR8 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 400-450
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Verwendungszweck
- Rabbit anti-DGCR8 Antibody, Affinity Purified
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Aufreinigung
- Affinity Purified
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Immunogen
- between AA 400 and 450
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Isotyp
- IgG
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Applikationshinweise
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IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
IP: 2 - 5 μg/mg lysate
WB: Not recommended. Use rabbit anti-DGCR8 antibody A302-468A.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 1000 μg/mL
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Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C
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Haltbarkeit
- 12 months
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- DGCR8 (DiGeorge Syndrome Critical Region Gene 8 (DGCR8))
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Andere Bezeichnung
- DGCR8
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Hintergrund
- Background: DiGeorge syndrome critical region 8 (DGCR8) is a component of the microprocessor complex that acts as a RNA- and heme-binding protein and is involved in the initial step of microRNA (miRNA) biogenesis. DGCR8 functions as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junctions. It directs RNASEN/DROSHA to cleave 11 bp away from the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs [taken from the Universal Protein Resource (UniProt) Q8WYQ5].
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Gen-ID
- 54487
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NCBI Accession
- NP_073557
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UniProt
- Q8WYQ5
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Pathways
- Regulatorische RNA Pathways
Target
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