TDP2 Antikörper (AA 50-100)

Produktnummer ABIN7453801

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch TDP2 in WB, IP und IHC (fp). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für TDP2 Antikörper (AA 50-100) (ABIN7453801)

Target: TDP2 (tyrosyl-DNA phosphodiesterase 2 (TDP2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TDP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Produktdetails anti-TDP2 Antikörper

Bindungsspezifität: AA 50-100

Verwendungszweck: Rabbit anti-TDP2 Antibody, Affinity Purified

Aufreinigung: Affinity Purified

Immunogen: between AA 50 and 100

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IHC: 1:100 - 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu TDP2

Target: TDP2 (tyrosyl-DNA phosphodiesterase 2 (TDP2))

Andere Bezeichnung: TDP2

Hintergrund: Background: TDP2 (5'-Tyr-DNA phosphodiesterase 2) is also known as TTRAP (TRAF and TNF receptor-associated protein). TTRAP is a DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. It catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. TTRAP also hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. TTRAP may also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation [taken from the Universal Protein Resource (UniProt) O95551].

Gen-ID: 51567

NCBI Accession: NP_057698

UniProt: O95551