Apoptosis Inhibitor 5 Antikörper (AA 1-50)
Kurzübersicht für Apoptosis Inhibitor 5 Antikörper (AA 1-50) (ABIN7453657)
Target
Alle Apoptosis Inhibitor 5 (API5) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
-
-
Bindungsspezifität
- AA 1-50
-
Verwendungszweck
- Rabbit anti-API5 Antibody, Affinity Purified
-
Homologie
- X. laevis,Chicken,Orangutan
-
Aufreinigung
- Affinity Purified
-
Immunogen
- between AA 1 and 50
-
Isotyp
- IgG
-
-
-
-
Applikationshinweise
-
IHC: 1:100 - 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
IP: 2 - 5 μg/mg lysate
WB: 1:2,000 - 1:10,000
-
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Konzentration
- 200 μg/mL
-
Buffer
- Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide
-
Konservierungsmittel
- Sodium azide
-
Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Lagerung
- 4 °C
-
Haltbarkeit
- 12 months
-
-
- Apoptosis Inhibitor 5 (API5)
-
Andere Bezeichnung
- API5
-
Hintergrund
- Background: API5 (apoptosis inhibitor 5) is an antiapoptotic factor that may have a role in protein assembly. API5 negatively regulates ACIN1. By binding to ACIN1, API5 suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. API5 is also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.
-
Gen-ID
- 8539
-
NCBI Accession
- XP_508375
-
UniProt
- Q9BZZ5
-
Pathways
- Growth Factor Binding
Target
-