Cyclin T1 Antikörper (AA 625-675)
Kurzübersicht für Cyclin T1 Antikörper (AA 625-675) (ABIN7453625)
Target
Alle Cyclin T1 (CCNT1) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 625-675
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Verwendungszweck
- Rabbit anti-Cyclin T1 Antibody, Affinity Purified
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Homologie
- Chimpanzee
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Aufreinigung
- Affinity Purified
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Immunogen
- between AA 625 and 675
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Isotyp
- IgG
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Applikationshinweise
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IHC: 1:100 - 1:500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
IP: 2 - 10 μg/mg lysate
WB: 1:2,000 - 1:10,000
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 200 μg/mL
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Buffer
- Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C
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Haltbarkeit
- 12 months
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- Cyclin T1 (CCNT1)
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Andere Bezeichnung
- Cyclin T1
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Hintergrund
- Background: Cyclin T1 is a regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). In case of HIV or SIV infections, Cyclin T1 binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA) [taken from the Universal Protein Resource (UniProt) O60563].
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Gen-ID
- 904
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NCBI Accession
- NP_001231
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UniProt
- O60563
Target
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