NOC2L Antikörper (AA 699-749)
Kurzübersicht für NOC2L Antikörper (AA 699-749) (ABIN7453539)
Target
Alle NOC2L Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 699-749
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Verwendungszweck
- Rabbit anti-NIR Antibody, Affinity Purified
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Aufreinigung
- Affinity Purified
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Immunogen
- Between AA 699 and 749
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Isotyp
- IgG
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Applikationshinweise
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IHC: 1:1,000 - 1:5,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
IP: Not recommended
WB: 1:2,000 - 1:10,000
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 1000 μg/mL
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Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C
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Haltbarkeit
- 12 months
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- NOC2L (Nucleolar Complex Associated 2 Homolog (NOC2L))
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Andere Bezeichnung
- NIR
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Hintergrund
- Background: Novel INHAT repressor (NIR) acts as an inhibitor of histone acetyltransferase activity, it prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. NIR acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. It is involved in the regulation of p53/TP53-dependent apoptosis and it associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter [taken from the Universal Protein Resource (UniProt) Q9Y3T9].
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Gen-ID
- 26155
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NCBI Accession
- NP_056473
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UniProt
- Q9Y3T9
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Pathways
- Negative Regulation of intrinsic apoptotic Signaling
Target
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