Sestrin 2 Antikörper (AA 275-325)

Produktnummer ABIN7452840

Dieses Anti-Sestrin 2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Sestrin 2 in WB und IP. Geeignet für Human.

Kurzübersicht für Sestrin 2 Antikörper (AA 275-325) (ABIN7452840)

Target: Sestrin 2 (SESN2)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Sestrin 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Produktdetails anti-Sestrin 2 Antikörper

Bindungsspezifität: AA 275-325

Verwendungszweck: Rabbit anti-SESN2 Antibody, Affinity Purified

Homologie: Mouse,Orangutan

Aufreinigung: Affinity Purified

Immunogen: between AA 275 and 325

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: 50-100 μL/mg lysate

WB: 1:10,000 - 1:25,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu Sestrin 2

Target: Sestrin 2 (SESN2)

Andere Bezeichnung: SESN2

Hintergrund: Background: SESN2 functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. SESN2 may negatively regulate protein translation in response to endoplasmic reticulum stress, via TORC1, and may positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1. May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress, and has an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein.  [taken from the Universal Protein Resource (UniProt) P58004].

Gen-ID: 83667

UniProt: P58004