CCDC22 Antikörper (AA 577-627)
Kurzübersicht für CCDC22 Antikörper (AA 577-627) (ABIN7452809)
Target
Alle CCDC22 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 577-627
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Verwendungszweck
- Rabbit anti-CCDC22 Antibody, Affinity Purified
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Homologie
- Bovine
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Aufreinigung
- Affinity Purified
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Immunogen
- between AA 577 and 627
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Isotyp
- IgG
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Applikationshinweise
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IP: 50-100 μL/mg lysate
WB: 1:10,000 - 1:25,000
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 1000 μg/mL
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Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C
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Haltbarkeit
- 12 months
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- CCDC22 (Coiled-Coil Domain Containing 22 (CCDC22))
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Andere Bezeichnung
- CCDC22
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Hintergrund
- Background: CCDC22 is involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation, the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10. Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery, the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes. [taken from the Universal Protein Resource (UniProt) O60826].
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Gen-ID
- 28952
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UniProt
- O60826
Target
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