DUSP12 Antikörper (AA 1-50)

Produktnummer ABIN7452603

Dieses Anti-DUSP12-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von DUSP12 in WB und IP. Geeignet für Human.

Kurzübersicht für DUSP12 Antikörper (AA 1-50) (ABIN7452603)

Target: DUSP12 (Dual Specificity Phosphatase 12 (DUSP12))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DUSP12 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Produktdetails anti-DUSP12 Antikörper

Bindungsspezifität: AA 1-50

Verwendungszweck: Rabbit anti-DUSP12 Antibody, Affinity Purified

Aufreinigung: Affinity Purified

Immunogen: Between AA 1 and 50

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: 20 μL/mg lysate

WB: 1:2,000 - 1:10,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu DUSP12

Target: DUSP12 (Dual Specificity Phosphatase 12 (DUSP12))

Andere Bezeichnung: DUSP12

Hintergrund: Background: Dual specificity protein phosphatase 12 (DUSP12) is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP12 is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain [taken from NCBI Entrez Gene (Gene ID: 11266)].

Gen-ID: 11266

UniProt: Q9UNI6

Pathways: Regulation of Carbohydrate Metabolic Process