USP1 Antikörper (AA 584-634)

Produktnummer ABIN7452551

Der Kaninchen Polyklonal Anti-USP1-Antikörper wurde für IP validiert. Er ist geeignet, USP1 in Proben von Human zu detektieren.

Kurzübersicht für USP1 Antikörper (AA 584-634) (ABIN7452551)

Target: USP1 (Ubiquitin Specific Peptidase 1 (USP1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser USP1 Antikörper ist unkonjugiert

Applikation: Immunoprecipitation (IP)

Produktdetails anti-USP1 Antikörper

Bindungsspezifität: AA 584-634

Verwendungszweck: Rabbit anti-USP1 Antibody, Affinity Purified

Homologie: Rat

Aufreinigung: Affinity Purified

Immunogen: between AA 584 and 634

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: 2 - 5 μg/mg lysate

WB: Not recommended

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu USP1

Target: USP1 (Ubiquitin Specific Peptidase 1 (USP1))

Andere Bezeichnung: USP1

Hintergrund: Background: Ubiquitin (Ub) is a highly conserved protein found ubiquitously in eukaryotic organisms. The conjugation of ubiquitin to proteins is an important means to regulate protein activity for many cellular processes by tagging them for degradation. Removal of Ub can rescue proteins from degradation. This is accomplished by the ubiquitin-specific processing protease (UBP) family of enzymes. Ubiquitin specific processing protease 1 (USP1) has been found to play a role in the Fanconi anemia DNA repair pathway. USP1 specifically removes monoubiquitination from the Fanconi anemia D2 (FANCD2) protein and from the proliferating cell nuclear antigen (PCNA). Deubiquitination of FANCD2 and PCNA is critical to their role in the DNA damage response and DNA crosslink repair.

Gen-ID: 7398

NCBI Accession: NP_003359

UniProt: O94782