USP20 Antikörper (AA 863-913)
Kurzübersicht für USP20 Antikörper (AA 863-913) (ABIN7452141)
Target
Alle USP20 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 863-913
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Verwendungszweck
- Rabbit anti-USP20/VDU2 Antibody, Affinity Purified
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Aufreinigung
- Affinity Purified
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Immunogen
- between AA 863 and 913
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Isotyp
- IgG
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Applikationshinweise
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IP: 2 - 5 μg/mg lysate
WB: 1:2,000 - 1:10,000
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 1000 μg/mL
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Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C
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Haltbarkeit
- 12 months
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- USP20 (Ubiquitin Specific Peptidase 20 (USP20))
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Andere Bezeichnung
- USP20/VDU2
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Hintergrund
- Background: The conjugation of ubiquitin to proteins is an important means to regulate protein activity for many cellular processes by tagging them for degradation. Removal of Ub can rescue proteins from degradation. This is accomplished by the ubiquitin-specific processing protease (UBP) family of enzymes. Ubiquitin specific peptidase 20 (USP20) is a UBP and is also called von-Hippel-Lindau protein (pVHL) interacting deubiquitinating enzyme 2 (VDU2). pVHL is an E3 ubiquitin-ligase that ubiquitinates hypoxia-inducible factor (HIF)-1alpha. USP20/VDU2 functions to specifically deubiquitinate HIF-1alpha to increase expression of HIF-1alpha regulated genes.
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Gen-ID
- 10868
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NCBI Accession
- NP_006667
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UniProt
- Q9Y2K6
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Pathways
- Regulation of G-Protein Coupled Receptor Protein Signaling
Target
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