TNKS1BP1 Antikörper (AA 350-400)

Produktnummer ABIN7452083

Produktdetails anti-TNKS1BP1 Antikörper

Target: TNKS1BP1 (Tankyrase 1 Binding Protein 1, 182kDa (TNKS1BP1))

Bindungsspezifität: AA 350-400

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TNKS1BP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Verwendungszweck: Rabbit anti-TAB182 Antibody, Affinity Purified

Aufreinigung: Affinity Purified

Immunogen: between AA 350 and 400

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu TNKS1BP1

Target: TNKS1BP1 (Tankyrase 1 Binding Protein 1, 182kDa (TNKS1BP1))

Andere Bezeichnung: TAB182 (TNKS1BP1 Produkte)

Synonyme: TAB182 antikoerper, Tab182 antikoerper, mKIAA1741 antikoerper, tankyrase 1 binding protein 1 antikoerper, 182 kDa tankyrase-1-binding protein antikoerper, TNKS1BP1 antikoerper, LOC100625088 antikoerper, Tnks1bp1 antikoerper

Hintergrund: Background: TAB182 (tankyrase 1-binding protein of 182 kDa) was identified in a two-hybrid screen in search of tankyrase 1-interacting proteins. Tankyrase 1 is a poly (ADP-ribose) polymerase (PARP) that ribosylates the negative regulator of telomere length, TRF1 (telomere-repeat binding factor). Ribosylation of TRF1 has been shown to result in the inhibition of TRF1 binding and an induction of telomere elongation. TAB182 and TRF1 bind multiple discrete and overlapping sites of the tankyrase 1 ankyrin domain. This finding suggests that TAB182 may act as a scaffold to mediate higher order protein complex formation at telomeres. TAB182 has also been suggested to serve a role in the cytoplasm as it has been found to localize to the cytoplasmic cortical actin network.

Gen-ID: 85456

NCBI Accession: NP_203754

UniProt: Q9C0C2