CIZ1 Antikörper (AA 848-898)

Produktnummer ABIN7451705

Der Kaninchen Polyklonal Anti-CIZ1-Antikörper wurde für WB und IP validiert. Er ist geeignet, CIZ1 in Proben von Human zu detektieren.

Kurzübersicht für CIZ1 Antikörper (AA 848-898) (ABIN7451705)

Target: CIZ1 (CDKN1A Interacting Zinc Finger Protein 1 (CIZ1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CIZ1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Produktdetails anti-CIZ1 Antikörper

Bindungsspezifität: AA 848-898

Verwendungszweck: Rabbit anti-CIZ1 Antibody, Affinity Purified

Aufreinigung: Affinity Purified

Immunogen: between AA 848 and 898

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu CIZ1

Target: CIZ1 (CDKN1A Interacting Zinc Finger Protein 1 (CIZ1))

Andere Bezeichnung: CIZ1

Hintergrund: Background: CIZ1 (Cip1 interacting zinc-finger protein) was identified as a protein that associates with the cell-cycle inhibiting protein, p21 (Cip1/Waf1). CIZ1 is a member of the matrin 3 protein family and has been shown to bind DNA consensus sequences and co-localize with PCNA during replication. In breast cancer cells, CIZ1 was shown to associate with Cdk2 and dynein light chain 1 (DLC1), a cytoskeletal signaling protein involved in cell cycle regulation and tumorigenesis. Studies of the role of CIZ1 in breast tumorigenesis revealed that CIZ1 is an estrogen-responsive gene that functions as a coactivator of the estrogen receptor. Targeted depletion of CIZ1 inhibits entry into S-phase. This finding along with evidence that CIZ1 interacts with multiple cell cycle regulatory proteins and localizes to DNA replication foci, indicates that CIZ1 plays a critical role in the regulation of DNA replication.

Gen-ID: 25792

NCBI Accession: NP_036259

UniProt: Q9ULV3

Pathways: Maintenance of Protein Location