USP11 Antikörper (AA 870-920)

Produktnummer ABIN7450882

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch USP11 in WB und IP. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für USP11 Antikörper (AA 870-920) (ABIN7450882)

Target: USP11 (Ubiquitin Specific Peptidase 11 (USP11))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser USP11 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Produktdetails anti-USP11 Antikörper

Bindungsspezifität: AA 870-920

Verwendungszweck: Rabbit anti-USP11 Antibody, Affinity Purified

Aufreinigung: Affinity Purified

Immunogen: Between AA 870 and 920

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu USP11

Target: USP11 (Ubiquitin Specific Peptidase 11 (USP11))

Andere Bezeichnung: USP11

Hintergrund: Background: Ubiquitin (Ub) is a highly conserved protein found ubiquitously in eukaryotic organisms. The conjugation of ubiquitin to proteins is an important means to regulate protein activity for many cellular processes by tagging them for degradation. Removal of Ub can rescue proteins from degradation. This is accomplished by the ubiquitin-specific processing protease (UBP) family of enzymes. Ubiquitin specific processing protease 11 (USP11) is a member of this family. USP11 has been found to associate with several proteins and may have functions independent of its deubiquitinating activity. USP11 deubiquitinates and associates with the RanGTP-binding protein, RanBPM. It has also been found to associate with BRCA2 and participate in the BRCA2 DNA damage related pathway, however, it does not appear to be involved in BRCA2 deubiquitination. USP11 also appears to play a role in the regulation of the IKKalpha and p53 signaling pathway by a mechanism independent of it deubiquitination activity.

Gen-ID: 8237

UniProt: P51784