MRGPRX1/3/4 (AA 21-120) Antikörper (HRP)

Produktnummer ABIN718760

Der Kaninchen Polyklonal Anti--Antikörper wurde für ELISA, IHC (fro) und IHC (p) validiert. Er ist geeignet, in Proben von Human zu detektieren.

Kurzübersicht für MRGPRX1/3/4 (AA 21-120) Antikörper (HRP) (ABIN718760)

Target: MRGPRX1/3/4

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: HRP

Applikation: ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails

Bindungsspezifität: AA 21-120

Spezifität: This may preferentially target MRGPRX1 over 3 and 4 due to slightly higher sequence similarity.

Kreuzreaktivität: Human

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MRGX1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: MRGPRX1/3/4

Hintergrund:

Synonyms: MRGPRC, G protein coupled receptor MRGX1, G protein coupled receptor SNSR3, GPCR, Mas related G protein coupled receptor member X1, MAS related gene MRGX1, MAS related GPR member X1, MRGPRX1, MRGX1, Sensory neuron specic G protein coupled receptor 3/4, Seven transmembrane helix receptor, SNSR3, SNSR4, MRGX1_HUMAN, MRGPRX3, MRGX3, MRGPRX4, MRGX4, SNSR5, SNSR6, SNSR1, SNSR2.

Background: There are four members (MRGX1-4) in the human MRGX familly. MRGX1 and MRGX2 receptors stimulate both G Alpha q- and G Alpha i -regulated pathways, while MRGX3 and MRGX4 receptors mainly activate G Alpha q-regulated pathways. G Alpha q proteins are involved in the calcium-signaling pathway downstream of the MRGX receptors. MRGX receptors are unique in that they are expressed in a subset of small dorsal root and trigeminal sensory neurons. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway.

Gen-ID: 259249, 117195, 117196