PAN3 Antikörper (AA 175-225)

Produktnummer ABIN7450539

Der Kaninchen Polyklonal anti-PAN3 Antikörper (ABIN7450539) detektiert spezifisch PAN3 in WB und IP. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für PAN3 Antikörper (AA 175-225) (ABIN7450539)

Target: PAN3 (PAN3 Poly(A) Specific Ribonuclease Subunit Homolog (PAN3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PAN3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Produktdetails anti-PAN3 Antikörper

Bindungsspezifität: AA 175-225

Verwendungszweck: Rabbit anti-PAN3 Antibody, Affinity Purified

Aufreinigung: Affinity Purified

Immunogen: Between AA 175 and 225

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu PAN3

Target: PAN3 (PAN3 Poly(A) Specific Ribonuclease Subunit Homolog (PAN3))

Andere Bezeichnung: PAN3

Hintergrund: Background: PAB-dependent poly(A)-specific ribonuclease subunit PAN3 is a regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with PABP and to miRNA targets via its interaction with GW182 family proteins [taken from the Universal Protein Resource (UniProt) Q58A45].

Gen-ID: 255967

UniProt: Q58A45