PAN2 Antikörper (AA 1-50)

Produktnummer ABIN7450538

Produktdetails anti-PAN2 Antikörper

Target: PAN2 (PAN2 Poly(A) Specific Ribonuclease Subunit Homolog (PAN2))

Bindungsspezifität: AA 1-50

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PAN2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Verwendungszweck: Rabbit anti-PAN2/USP52 Antibody, Affinity Purified

Homologie: Rat

Aufreinigung: Affinity Purified

Immunogen: Between AA 1 and 50

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu PAN2

Target: PAN2 (PAN2 Poly(A) Specific Ribonuclease Subunit Homolog (PAN2))

Andere Bezeichnung: PAN2/USP52 (PAN2 Produkte)

Synonyme: USP52 antikoerper, 1200014O24Rik antikoerper, AI047843 antikoerper, AW742773 antikoerper, Usp52 antikoerper, mKIAA0710 antikoerper, PAN2 antikoerper, pan2 antikoerper, PAN2 poly(A) specific ribonuclease subunit antikoerper, PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae) antikoerper, PAN2 poly(A) specific ribonuclease subunit S homeolog antikoerper, PAN2 antikoerper, Pan2 antikoerper, pan2.S antikoerper

Hintergrund: Background: PAB-dependent poly(A)-specific ribonuclease subunit PAN2 is the catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1 [taken from the Universal Protein Resource (UniProt) Q504Q3].

Gen-ID: 9924

UniProt: Q504Q3