FERMT2 Antikörper (AA 175-225)

Produktnummer ABIN7450396

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch FERMT2 in WB und IP. Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für FERMT2 Antikörper (AA 175-225) (ABIN7450396)

Target: FERMT2 (Fermitin Family Member 2 (FERMT2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FERMT2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Produktdetails anti-FERMT2 Antikörper

Bindungsspezifität: AA 175-225

Verwendungszweck: Rabbit anti-Kindlin-2 Antibody, Affinity Purified

Aufreinigung: Affinity Purified

Immunogen: Between AA 175 and 225

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu FERMT2

Target: FERMT2 (Fermitin Family Member 2 (FERMT2))

Andere Bezeichnung: Kindlin-2

Hintergrund: Background: Kindlin-2 is a scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. It binds to membranes enriched in phosphoinositides. It also enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading, this requires both its ability to interact with integrins and with phospholipid membranes. Kindlin-2 is required for the assembly of focal adhesions and participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Kindlin-2 recruits FBLIM1 to focal adhesions. It plays a role in the TGFB1 and integrin signaling pathways, and it stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling [taken from the Universal Protein Resource (UniProt) Q96AC1].

Gen-ID: 10979

NCBI Accession: NP_006823

UniProt: Q96AC1

Pathways: Cell-Cell Junction Organization