Importin 11 Antikörper (AA 925-975)

Produktnummer ABIN7450360

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Importin 11 in WB und IP. Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für Importin 11 Antikörper (AA 925-975) (ABIN7450360)

Target: Importin 11 (IPO11)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Importin 11 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Produktdetails anti-Importin 11 Antikörper

Bindungsspezifität: AA 925-975

Verwendungszweck: Rabbit anti-Importin 11/IPO11 Antibody, Affinity Purified

Aufreinigung: Affinity Purified

Immunogen: Between AA 925 and 975

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu Importin 11

Target: Importin 11 (IPO11)

Andere Bezeichnung: Importin 11/IPO11

Hintergrund: Background: Importin 11 functions in nuclear protein import as nuclear transport receptor. It serves as receptor for nuclear localization signals (NLS) in cargo substrates, and is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Importin 11/IPO11 mediates the nuclear import of UBE2E3, and of RPL12 (By similarity) [taken from the Universal Protein Resource (UniProt) Q9UI26].

Gen-ID: 51194

UniProt: Q9UI26

Pathways: Protein targeting to Nucleus