P4HTM Antikörper (C-Term)
Kurzübersicht für P4HTM Antikörper (C-Term) (ABIN7449275)
Target
Alle P4HTM Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- C-Term
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Verwendungszweck
- Rabbit anti-PHD4 Antibody, Affinity Purified
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Aufreinigung
- Affinity Purified
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Immunogen
- between AA 450 and C-term
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Isotyp
- IgG
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Applikationshinweise
- 1:500 - 1:2,500
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 1000 μg/mL
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Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C
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Haltbarkeit
- 12 months
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- P4HTM (Prolyl 4-Hydroxylase, Transmembrane (Endoplasmic Reticulum) (P4HTM))
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Andere Bezeichnung
- PHD4
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Hintergrund
- Background: PHD4 is one of 4 PHD (PHD1-4) enzymes that function as oxygen sensors and are responsible for the post-translational modification of HIF-1alpha, a component of a transcriptional complex involved in oxygen homeostasis. During normoxic levels, PHDs catalyze the hydroxylation of prolyl residues on HIF-1alpha and target it for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. The PHD isoforms appear to function in a non-redundant manner and may differ in their expression patterns and their catalytic selectivity.
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Gen-ID
- 54681
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NCBI Accession
- NP_808808
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UniProt
- Q9NXG6
Target
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