CSN3 Antikörper (AA 325-375)
Kurzübersicht für CSN3 Antikörper (AA 325-375) (ABIN7449263)
Target
Alle CSN3 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 325-375
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Verwendungszweck
- Rabbit anti-CSN3 Antibody, Affinity Purified
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Homologie
- Mouse,Rat,Bovine,Orangutan
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Aufreinigung
- Affinity Purified
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Immunogen
- between AA 325 and 375
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Isotyp
- IgG
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Applikationshinweise
- 1:2,000 - 1:20,000
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 1000 μg/mL
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Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C
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Haltbarkeit
- 12 months
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- CSN3 (Casein kappa (CSN3))
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Andere Bezeichnung
- CSN3
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Hintergrund
- Background: CSN3 is one of eight subunits (CSN1 to 8) of the highly conserved COP9 signalsome (CSN) complex originally identified as a regulator of light-mediated development in Arabidopsis. Characterization of CSN from yeast to mammals reveals its function as a modulator of signal transduction pathways involved in a variety of cellular and developmental processes. One of the major functions of the CSN is the regulation of protein degradation via intersection with the ubiquitin-proteasome pathway and regulation of E3-ubiquitin ligases. The CSN also possesses kinase activity. CSN3 is the kinase associated with the CSN complex that phosphorylates signal transducers such as I-kappa-Balpha, p105, and c-Jun. Human CSN3 maps to the Smith-Magenis syndrome locus. Microdeletions in this locus results in mental retardation, skeletal abnormalities, sleep disorder, and neurobehavior anomalies.
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Gen-ID
- 8533
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NCBI Accession
- NP_003644
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UniProt
- Q9UNS2
Target
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