EGLN3 Antikörper (AA 50-100)
Kurzübersicht für EGLN3 Antikörper (AA 50-100) (ABIN7449245)
Target
Alle EGLN3 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 50-100
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Verwendungszweck
- Rabbit anti-PHD3 Antibody, Affinity Purified
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Aufreinigung
- Affinity Purified
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Immunogen
- between AA 50 and 100
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Isotyp
- IgG
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Applikationshinweise
- 1:2,000 - 1:10,000
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 1000 μg/mL
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Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C
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Haltbarkeit
- 12 months
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- EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))
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Andere Bezeichnung
- PHD3
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Hintergrund
- Background: PHD3 is one of 4 PHD (PHD1-4) enzymes that function as oxygen sensors and are responsible for the post-translational modification of HIF-1alpha, a component of a transcriptional complex involved in oxygen homeostasis. During normoxic levels, PHDs catalyze the hydroxylation of prolyl residues on HIF-1alpha and target it for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. The PHD isoforms appear to function in a non-redundant manner and may differ in their expression patterns and their catalytic selectivity.
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Gen-ID
- 112399
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NCBI Accession
- NP_071356
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UniProt
- Q9H6Z9
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Pathways
- Positive Regulation of Endopeptidase Activity
Target
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