SMG1 Antikörper (AA 1250-1300)

Produktnummer ABIN7449171

Produktdetails anti-SMG1 Antikörper

Target: SMG1 (pi-3-Kinase-Related Kinase SMG-1 (SMG1))

Bindungsspezifität: AA 1250-1300

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SMG1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: Rabbit anti-SMG1 Antibody, Affinity Purified

Homologie: Mouse

Aufreinigung: Affinity Purified

Immunogen: between AA 1250 and 1300

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: 1:1,000 - 1:10,000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu SMG1

Target: SMG1 (pi-3-Kinase-Related Kinase SMG-1 (SMG1))

Andere Bezeichnung: SMG1 (SMG1 Produkte)

Hintergrund: Background: SMG1 is a PIKK (phosphoinositide 3-kinase related kinases) protein kinase that plays a key role in RNA surveillance via nonsense-mediated mRNA decay (NMD). SMG1 phosphorylates Upf1, a factor that possesses RNA helicase activity and is also central to NMD. SMG1 and UPF-1 have been shown to exist in a complex with the translation termination release factors eRF3, and eRF1. This complex has been termed SURF and associates with the exon junction complex (EJC) to function in the recognition of premature termination codons in aberrant RNAs to trigger NMD.

Gen-ID: 23049

NCBI Accession: NP_055907

UniProt: Q96Q15

Pathways: Inositol Metabolic Process