SMG1 Antikörper (AA 1250-1300)
Kurzübersicht für SMG1 Antikörper (AA 1250-1300) (ABIN7449171)
Target
Alle SMG1 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 1250-1300
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Verwendungszweck
- Rabbit anti-SMG1 Antibody, Affinity Purified
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Homologie
- Mouse
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Aufreinigung
- Affinity Purified
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Immunogen
- between AA 1250 and 1300
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Isotyp
- IgG
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Applikationshinweise
- 1:1,000 - 1:10,000
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 1000 μg/mL
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Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C
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Haltbarkeit
- 12 months
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- SMG1 (pi-3-Kinase-Related Kinase SMG-1 (SMG1))
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Andere Bezeichnung
- SMG1
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Hintergrund
- Background: SMG1 is a PIKK (phosphoinositide 3-kinase related kinases) protein kinase that plays a key role in RNA surveillance via nonsense-mediated mRNA decay (NMD). SMG1 phosphorylates Upf1, a factor that possesses RNA helicase activity and is also central to NMD. SMG1 and UPF-1 have been shown to exist in a complex with the translation termination release factors eRF3, and eRF1. This complex has been termed SURF and associates with the exon junction complex (EJC) to function in the recognition of premature termination codons in aberrant RNAs to trigger NMD.
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Gen-ID
- 23049
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NCBI Accession
- NP_055907
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UniProt
- Q96Q15
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Pathways
- Inositol Metabolic Process
Target
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