METTL14 Antikörper (AA 75-125)

Produktnummer ABIN7449065

Der Kaninchen Polyklonal Anti-METTL14-Antikörper wurde für IP validiert. Er ist geeignet, METTL14 in Proben von Human zu detektieren.

Kurzübersicht für METTL14 Antikörper (AA 75-125) (ABIN7449065)

Target: METTL14 (Methyltransferase Like 14 (METTL14))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser METTL14 Antikörper ist unkonjugiert

Applikation: Immunoprecipitation (IP)

Produktdetails anti-METTL14 Antikörper

Bindungsspezifität: AA 75-125

Verwendungszweck: Rabbit anti-METTL14 Antibody, Affinity Purified

Homologie: Orangutan

Aufreinigung: Affinity Purified

Immunogen: between AA 75 and 125

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: 15-20 μL/mg lysate

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu METTL14

Target: METTL14 (Methyltransferase Like 14 (METTL14))

Andere Bezeichnung: METTL14

Hintergrund: Background: METTL14 forms a heterodimer with METTL3, creating an N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing. M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation (By similarity). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (By similarity). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity). [taken from the Universal Protein Resource (UniProt) Q9HCE5].

Gen-ID: 57721

UniProt: Q9HCE5