CHCHD4 Antikörper (AA 92-142)

Produktnummer ABIN7449057

Dieses Anti-CHCHD4-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CHCHD4 in IP. Geeignet für Human.

Kurzübersicht für CHCHD4 Antikörper (AA 92-142) (ABIN7449057)

Target: CHCHD4 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CHCHD4 Antikörper ist unkonjugiert

Applikation: Immunoprecipitation (IP)

Produktdetails anti-CHCHD4 Antikörper

Bindungsspezifität: AA 92-142

Verwendungszweck: Rabbit anti-CHCHD4 Antibody, Affinity Purified

Aufreinigung: Affinity Purified

Immunogen: between AA 92 and 142

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: 15-20 μL/mg lysate

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu CHCHD4

Target: CHCHD4 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4))

Andere Bezeichnung: CHCHD4

Hintergrund: Background: CHCHD4 functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17, COX19 and MICU1. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS. Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system. Mediates formation of disulfide bond in MICU1 in the IMS, promoting formation of the MICU1-MICU2 heterodimer that regulates mitochondrial calcium uptake. [taken from the Universal Protein Resource (UniProt) Q8N4Q1].

Gen-ID: 131474

UniProt: Q8N4Q1