CD8 alpha Antikörper (C-Term, Cytoplasmic Domain)

Produktnummer ABIN7449043

Dieses Maus Monoklonal-Antikörper erkennt spezifisch CD8 alpha in FACS, IHC und IF (p). Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für CD8 alpha Antikörper (C-Term, Cytoplasmic Domain) (ABIN7449043)

Target: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD8 alpha Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Klon: C8-144B

Produktdetails anti-CD8 alpha Antikörper

Bindungsspezifität: C-Term, Cytoplasmic Domain

Verwendungszweck: Mouse anti-CD8 alpha Monoclonal Antibody, Purified [C8/144B]

Aufreinigung: Purified

Immunogen: A 13 amino acid synthetic peptide from the C-terminal cytoplasmic domain of alpha chain of human CD8 molecule

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

IHC-IF: 1:100 to 1:500. Epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections.

IHC: 1:100 - 1:500. Epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 250 μg/mL

Buffer: Borate Buffered Saline (BBS) pH 8.2 with 0.1 % BSA and 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu CD8 alpha

Target: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Andere Bezeichnung: CD8 alpha

Hintergrund: Background: The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain [taken from NCBI Entrez Gene (Gene ID: 925)].

Gen-ID: 925

NCBI Accession: NP_001759

UniProt: P01732

Pathways: T-Zell Rezeptor Signalweg