USP1 Antikörper (AA 450-500)

Produktnummer ABIN7448850

Dieses Anti-USP1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von USP1 in IHC. Geeignet für Human.

Kurzübersicht für USP1 Antikörper (AA 450-500) (ABIN7448850)

Target: USP1 (Ubiquitin Specific Peptidase 1 (USP1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser USP1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-USP1 Antikörper

Bindungsspezifität: AA 450-500

Verwendungszweck: Rabbit anti-USP1 IHC Antibody, Affinity Purified

Homologie: Mouse,Rat,Chicken,Turkey,Bovine,Dog,Horse,Rabbit,Guinea pig_10141,Pig,Panda,Orangutan,Monkey,Gorilla,Chimpanzee,African elephant,Zebra finch,Ferret,Northern white-cheeked gibbon,Crab-eating macaque,Thirteen-lined ground squirrel,Little brown bat,Naked mole rat,Small-eared galago,White-tufted-ear marmoset

Aufreinigung: Affinity Purified

Immunogen: Between AA 450 and 500

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: 1:100 - 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 100 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu USP1

Target: USP1 (Ubiquitin Specific Peptidase 1 (USP1))

Andere Bezeichnung: USP1

Hintergrund: Background: Ubiquitin (Ub) is a highly conserved protein found ubiquitously in eukaryotic organisms. The conjugation of ubiquitin to proteins is an important means to regulate protein activity for many cellular processes by tagging them for degradation. Removal of Ub can rescue proteins from degradation. This is accomplished by the ubiquitin-specific processing protease (UBP) family of enzymes. Ubiquitin specific processing protease 1 (USP1) has been found to play a role in the Fanconi anemia DNA repair pathway. USP1 specifically removes monoubiquitination from the Fanconi anemia D2 (FANCD2) protein and from the proliferating cell nuclear antigen (PCNA). Deubiquitination of FANCD2 and PCNA is critical to their role in the DNA damage response and DNA crosslink repair.

Gen-ID: 7398

NCBI Accession: NP_003359

UniProt: O94782