MTA3 Antikörper (AA 400-450)
Kurzübersicht für MTA3 Antikörper (AA 400-450) (ABIN7448677)
Target
Alle MTA3 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 400-450
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Verwendungszweck
- Rabbit anti-MTA3 IHC Antibody, Affinity Purified
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Homologie
- Orangutan,Monkey,Chimpanzee,White-tufted-ear marmoset,Crab-eating macaque,Northern white-cheeked gibbon,Small-eared galago
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Aufreinigung
- Affinity Purified
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Immunogen
- Between AA 400 and 450
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Isotyp
- IgG
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Applikationshinweise
- 1:100 - 1:500
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 250 μg/mL
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Buffer
- Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C
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Haltbarkeit
- 12 months
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- MTA3 (Metastasis Associated 1 Family, Member 3 (MTA3))
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Andere Bezeichnung
- MTA3
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Hintergrund
- Background: MTA3 (metastasis-associated protein 3) is a component of the NuRD (nucleosome remodeling and histone deacetylation) complex. MTA3 is a member of a family of proteins (MTA1-3) differentially expressed in metastatic breast cancer cells. MTA3 functions as a repressor of the transcription factor Snail, a factor involved in epithelial to mesenchymal transitions. MTA3 expression is estrogen dependent in breast cancer cells. Studies show that ERalpha selectively bind the MTA3 promoter in an SP1-dependent fashion to stimulate MTA3 gene transcription.
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Gen-ID
- 57504
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NCBI Accession
- NP_001317371
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UniProt
- Q9BTC8
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Pathways
- Chromatin Binding
Target
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