CSN3 Antikörper (AA 325-375)

Produktnummer ABIN7448493

Dieses Anti-CSN3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CSN3 in IHC. Geeignet für Human.

Kurzübersicht für CSN3 Antikörper (AA 325-375) (ABIN7448493)

Target: CSN3 (Casein kappa (CSN3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CSN3 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-CSN3 Antikörper

Bindungsspezifität: AA 325-375

Verwendungszweck: Rabbit anti-CSN3 IHC Antibody, Affinity Purified

Homologie: Mouse,Rat,X. tropicalis,Chicken,Turkey,Bovine,Dog,Horse,Guinea pig_10141,Panda,Orangutan,Monkey,Chimpanzee,White-tufted-ear marmoset,Crab-eating macaque,Tasmanian devil,African elephant,Green anole,Small-eared galago,Gray short-tailed opossum,Naked mole rat,Chinese hamster,Thirteen-lined ground squirrel,Duckbill platypus,West Indian ocean coelacanth,Little brown bat,Zebra finch,Northern white-cheeked gibbon

Aufreinigung: Affinity Purified

Immunogen: Between AA 325 and 375

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: 1:100 - 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 250 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Haltbarkeit: 12 months

Details zu CSN3

Target: CSN3 (Casein kappa (CSN3))

Andere Bezeichnung: CSN3

Hintergrund: Background: CSN3 is one of eight subunits (CSN1 to 8) of the highly conserved COP9 signalsome (CSN) complex originally identified as a regulator of light-mediated development in Arabidopsis. Characterization of CSN from yeast to mammals reveals its function as a modulator of signal transduction pathways involved in a variety of cellular and developmental processes. One of the major functions of the CSN is the regulation of protein degradation via intersection with the ubiquitin-proteasome pathway and regulation of E3-ubiquitin ligases. The CSN also possesses kinase activity. CSN3 is the kinase associated with the CSN complex that phosphorylates signal transducers such as I-kappa-Balpha, p105, and c-Jun. Human CSN3 maps to the Smith-Magenis syndrome locus. Microdeletions in this locus results in mental retardation, skeletal abnormalities, sleep disorder, and neurobehavior anomalies.

Gen-ID: 8533

NCBI Accession: NP_003644

UniProt: Q9UNS2