Rekombinanter MUC16 (Sofituzumab Biosimilar) Antikörper

Produktnummer ABIN7488033

Der Mammalian Cells Monoklonal anti-MUC16 (Sofituzumab Biosimilar) Antikörper (ABIN7488033) detektiert spezifisch MUC16 (Sofituzumab Biosimilar) in ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Rekombinanter MUC16 (Sofituzumab Biosimilar) Antikörper (ABIN7488033)

Target: MUC16 (Sofituzumab Biosimilar)

Antikörpertyp: Recombinant Antibody

Reaktivität: Human

Wirt: Mammalian Cells

Klonalität: Monoklonal

Konjugat: Dieser MUC16 (Sofituzumab Biosimilar) Antikörper ist unkonjugiert

Applikation: ELISA

Güteklasse: Research Grade

Produktdetails anti-MUC16 (Sofituzumab Biosimilar) Antikörper

Expressionssystem: Mammalian cells

Verwendungszweck: Sofituzumab Biosimilar - Anti-MUC16, CA125 mAb

Produktmerkmale: Antibody Type: IgG1-kappa

Aufreinigung: Recombinant antibody expressed in mammalien cells and purified.

Isotyp: IgG1 kappa

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS pH 7.5

Lagerung: -80 °C

Informationen zur Lagerung: store at -80°C

Details zu MUC16 (Sofituzumab Biosimilar)

Target: MUC16 (Sofituzumab Biosimilar)

Substanzklasse: Biosimilar

Hintergrund: DMUC5754A (conjugate),MMUC1206A (nonconjugate)
Sofituzumab is investigated for the treatment of Platinum-Resistant Ovarian Cancer or Unresectable Pancreatic Cancer. Sofituzumab Vedotin (also known as DMUC5754A and RG-7458) is an antibody-drug conjugate (ADC) that contains the humanized IgG1 anti-MUC16 monoclonal antibody (mAb) and a potent anti-mitotic agent, monomethyl auristatin E (MMAE), linked through a protease-labile linker, maleimidocaproyl-valine-citrulline-p-aminobenzyloxycarbonyl. DMUC5754A binds to the MUC16 extracellular domain with high affinity, and shows potent and selective anti-tumor activity in MUC16-expressing human ovarian cancer (OC) and pancreatic cancer (PC) mouse xenograft models. The targeted therapeutic strategy of DMUC5754A resulted in enhanced tumor-specific activity of MMAE, while minimizing exposure to tissues that do not express MUC16.

CAS-Nummer: 1418200-58-4