C-AMP Protein Kinase (Catalytic Subunit) Antikörper

Produktnummer ABIN7384424

Dieser Kaninchen Monoklonal Antikörper detektiert spezifisch C-AMP Protein Kinase in WB, IP, IF und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für C-AMP Protein Kinase (Catalytic Subunit) Antikörper (ABIN7384424)

Target: C-AMP Protein Kinase

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: R07-8H3

Produktdetails

Bindungsspezifität: Catalytic Subunit

Aufreinigung: Affinity Purified

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000-1:2000 IHC 1:50-1:100 IF 1:50-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 300 μg/mL

Buffer: 50 mM Tris-Glycine( pH 7.4), 0.15M NaCl, 40 % Glycerol, 0.01 % Sodium azide and 0.05 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Antigendetails

Target: C-AMP Protein Kinase

Andere Bezeichnung: cAMP Protein Kinase

Hintergrund: CAMP dependent protein kinase alpha catalytic subunit,cAMP dependent protein kinase beta catalytic subunit,cAMP dependent protein kinase catalytic beta subunit isoform 4ab,cAMP dependent protein kinase catalytic subunit alpha,cAMP dependent protein kinase catalytic subunit alpha,isoform 1,cAMP dependent protein kinase catalytic subunit beta,cAMP-dependent protein kinase catalytic subunit alpha,KAPCA,PKA C alpha,PKA C beta,PKA C-alpha,PKACA,PKACB,PPNAD4,PRKACA,PRKACAA,PRKACB,Protein kinase A catalytic subunit alpha,Protein kinase A catalytic subunit,Protein kinase A catalytic subunit beta,Protein kinase cAMP dependent catalytic alpha,Protein kinase cAMP dependent catalytic beta,This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms.

Molekulargewicht:

Observed_MW: 41kDa

Calculated_MW: 41kDa

Gen-ID: 5566

UniProt: P17612