Rekombinanter SARS-CoV-2 Spike Antikörper (RBD)

Produktnummer ABIN7271740

Dieses Maus Chimeric-Antikörper erkennt spezifisch SARS-CoV-2 Spike in ELISA, Neut und SR. Er zeigt eine Reaktivität gegenüber SARS Coronavirus-2 (SARS-CoV-2).

Kurzübersicht für Rekombinanter SARS-CoV-2 Spike Antikörper (RBD) (ABIN7271740)

Target: SARS-CoV-2 Spike

Antikörpertyp: Recombinant Antibody

Reaktivität: SARS Coronavirus-2 (SARS-CoV-2)

Wirt: Maus

Klonalität: Chimeric

Konjugat: Dieser SARS-CoV-2 Spike Antikörper ist unkonjugiert

Applikation: ELISA, Neutralization (Neut), Spike and Recovery (SR)

Klon: AM122

Produktdetails anti-SARS-CoV-2 Spike Antikörper

Bindungsspezifität: RBD

Verwendungszweck: Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Chimeric mAb, Human IgG1 (AM122) (Trehalose free)

Spezifität: This product is a specific antibody against SARS-CoV-2 Spike protein RBD domain. No cross-reactivity is detected with Spike protein RBD domain of other coronaviruses, including SARS-CoV, MERS-CoV, HCoV-229E, HCoV-NL63, HCoV-OC43 and HCoV-HKU1.

Produktmerkmale: Recombinant Antibodies produced in HEK293. Anti-SARS-CoV-2 Spike RBD Antibody, Chimeric mAb, Human IgG1 (AM122) is a chimeric monoclonal antibody recombinantly expressed from HEK293 cells, which combines the variable region of a mouse monoclonal antibody with human IgG1 constant domain. The mouse monoclonal antibody was obtained from a mouse immunized with recombinant SARS-CoV-2 Spike S1 protein. As verified in competitive ELISA-based and pseudovirus-based neutralization assay, this chimeric monoclonal can potently neutralize all SARS-CoV-2 Variants of Concern (VOCs), including Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1) and Delta (B.1.617.2) .

Immunogen: Anti-SARS-CoV-2 Spike RBD Antibody, Chimeric mAb, Human IgG1 (AM122) is a chimeric monoclonal antibody recombinantly expressed from HEK293 cells, which combines the variable region of a mouse monoclonal antibody with human IgG1 constant domain. The mouse monoclonal antibody was obtained from a mouse immunized with recombinant SARS-CoV-2 Spike S1 protein. As verified in competitive ELISA-based and pseudovirus-based neutralization assay, this chimeric monoclonal can potently neutralize all SARS-CoV-2 Variants of Concern (VOCs), including Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1) and Delta (B.1.617.2) . 

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: This antibody can be paired with other Anti-SARS-CoV-2 Spike S1 antibodies to detect SARS-CoV-2 Spike S1 protein in sandwich ELISA or LFA assay.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Lagerung: -80 °C

Informationen zur Lagerung: -70°C

Details zu SARS-CoV-2 Spike

Target: SARS-CoV-2 Spike

Hintergrund: It's been reported that Coronavirus can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.