ZNF451 Antikörper (AA 600-900)

Produktnummer ABIN7271489

Produktdetails anti-ZNF451 Antikörper

Target: ZNF451 (Zinc Finger Protein 451 (ZNF451))

Bindungsspezifität: AA 600-900

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZNF451 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Verwendungszweck: ZNF451 Rabbit pAb

Sequenz: SSPRGKWQCR ICEDMFDSQE YVKQHCMSLA SHKFHRYSCA HCRKPFHKIE TLYRHCQDEH DNEIKIKYFC GLCDLIFNVE EAFLSHYEEH HSIDYVFVSE KTETSIKTED DFPVIETSNQ LTCGCRESYI CKVNRKEDYS RCLQIMLDKG KLWFRCSLCS ATAQNLTDMN THIHQVHKEK SDEEEQQYVI KCGTCTKAFH DPESAQQHFH RKHCFLQKPS VAHFGSEKSN LYKFTASASH TERKLKQAIN YSKSLDMEKG VENDLSYQNI EEEIVELPDL DYLRTMTHIV FVDFDNWSNF F

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 600-900 of human ZNF451 (NP_001026794.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:200 - 1:2000,IHC,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu ZNF451

Target: ZNF451 (Zinc Finger Protein 451 (ZNF451))

Andere Bezeichnung: ZNF451 (ZNF451 Produkte)

Hintergrund: E3 SUMO-protein ligase, has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins. Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro. Required for MCM4 sumoylation (By similarity. Has no activity with SUMO1. Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11'. Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9'. Plays a role in regulating the transcription of AR targets.,ZNF451,COASTER,dJ417I1.1,Epigenetics & Nuclear Signaling,Nuclear Receptor Signaling,Nuclear hormone receptors,Signal Transduction,ZNF451

Molekulargewicht: 63kDa/115kDa/121kDa

Gen-ID: 26036

UniProt: Q9Y4E5