TMED2 Antikörper (AA 60-170)

Produktnummer ABIN7270943

Der Kaninchen Polyklonal Anti-TMED2-Antikörper wurde für WB und IF validiert. Er ist geeignet, TMED2 in Proben von Human zu detektieren.

Kurzübersicht für TMED2 Antikörper (AA 60-170) (ABIN7270943)

Target: TMED2 (Transmembrane Emp24 Domain Trafficking Protein 2 (TMED2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TMED2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-TMED2 Antikörper

Bindungsspezifität: AA 60-170

Verwendungszweck: TMED2 Rabbit pAb

Sequenz: EITGPDNKGI YKGDRESSGK YTFAAHMDGT YKFCFSNRMS TMTPKIVMFT IDIGEAPKGQ DMETEAHQNK LEEMINELAV AMTAVKHEQE YMEVRERIHR AINDNTNSRV V

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 60-170 of human TMED2 (NP_006806.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu TMED2

Target: TMED2 (Transmembrane Emp24 Domain Trafficking Protein 2 (TMED2))

Andere Bezeichnung: TMED2

Hintergrund: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor, the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs. Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing.,P24A,RNP24,p24,p24b1,p24beta1,TMED2,Signal Transduction,Cell Biology & Developmental Biology,TMED2

Molekulargewicht: 22kDa

Gen-ID: 10959

UniProt: Q15363