TBC1D4 Antikörper (pSer588)

Produktnummer ABIN7270747

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch TBC1D4 in WB. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für TBC1D4 Antikörper (pSer588) (ABIN7270747)

Target: TBC1D4 (TBC1 Domain Family, Member 4 (TBC1D4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TBC1D4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-TBC1D4 Antikörper

Bindungsspezifität: pSer588

Verwendungszweck: Phospho-TBC1D4-S588 Rabbit pAb

Sequenz: LGSVD

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Phosphorylated Antibodies

Aufreinigung: Affinity purification

Immunogen: A synthetic phosphorylated peptide around S588 of human TBC1D4 (NP_055647.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu TBC1D4

Target: TBC1D4 (TBC1 Domain Family, Member 4 (TBC1D4))

Andere Bezeichnung: TBC1D4

Hintergrund: This gene is a member of the Tre-2/BUB2/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein, and contains two phopshotyrosine-binding domains (PTB1 and PTB2), a calmodulin-binding domain (CBD), a Rab-GTPase domain, and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin, this protein is phosphorylated, dissociates from GLUT4 vesicles, resulting in increased GLUT4 at the cell surface, and enhanced glucose transport. Phosphorylation of this protein by AKT is required for proper translocation of GLUT4 to the cell surface. Individuals homozygous for a mutation in this gene are at higher risk for type 2 diabetes and have higher levels of circulating glucose and insulin levels after glucose ingestion. Alternative splicing results in multiple transcript variants encoding different isoforms.,AS160,NIDDM5,TBC1D4,Signal Transduction,G protein signaling,Signal Transduction,PI3K-Akt Signaling Pathway,Endocrine & Metabolism,Insulin Receptor Signaling Pathway,Protein phosphorylation,TBC1D4

Molekulargewicht: 53kDa/60kDa/139kDa/145kDa/146kDa

Gen-ID: 9882

UniProt: O60343