SYNGAP1 Antikörper

Produktnummer ABIN7270663

Dieser Kaninchen Monoklonal Antikörper detektiert spezifisch SYNGAP1 in WB. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für SYNGAP1 Antikörper (ABIN7270663)

Target: SYNGAP1 (Synaptic Ras GTPase Activating Protein 1 (SYNGAP1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser SYNGAP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-SYNGAP1 Antikörper

Verwendungszweck: SynGAP Rabbit mAb

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Monoclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: A synthesized peptide derived from human SynGAP

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu SYNGAP1

Target: SYNGAP1 (Synaptic Ras GTPase Activating Protein 1 (SYNGAP1))

Andere Bezeichnung: SYNGAP1

Hintergrund: This gene encodes a Ras GTPase activating protein that is a member of the N-methyl-D-aspartate receptor complex. The N-terminal domain of the protein contains a Ras-GAP domain, a pleckstrin homology domain, and a C2 domain that may be involved in binding of calcium and phospholipids. The C-terminal domain consists of a ten histidine repeat region, serine and tyrosine phosphorylation sites, and a T/SXV motif required for postsynaptic scaffold protein interaction. The encoded protein negatively regulates Ras, Rap and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking to the postsynaptic membrane to regulate synaptic plasticity and neuronal homeostasis. Allelic variants of this gene are associated with intellectual disability and autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016],MRD5, RASA1, RASA5, SYNGAP,Cell Type Marker,Cell Type Marker_Neuron marker,Cell Type Marker_Synapse marker,G protein signaling,G protein signaling_G-Protein-Coupled Receptors Signaling to MAPK/Erk,Neuroscience,Signal Transduction,SYNGAP1

Molekulargewicht: 147kDa

Gen-ID: 8831

UniProt: Q96PV0

Pathways: Regulation of long-term Neuronal Synaptic Plasticity