Spt6 Antikörper (AA 1500-1726)

Produktnummer ABIN7270645

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Spt6 in WB, IP und IF. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für Spt6 Antikörper (AA 1500-1726) (ABIN7270645)

Target: Spt6 (SUPT6H) (Suppressor of Ty 6 Homolog (SUPT6H))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Spt6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF)

Produktdetails anti-Spt6 Antikörper

Bindungsspezifität: AA 1500-1726

Verwendungszweck: SUPT6H Rabbit pAb

Sequenz: IFPTVNGLFR WFKDHYQDPV PGITPSSSSR TRTPASINAT PANINLADLT RAVNALPQNM TSQMFSAIAA VTGQGQNPNA TPAQWASSQY GYGGSGGGSS AYHVFPTPAQ QPVATPLMTP SYSYTTPSQP ITTPQYHQLQ ASTTPQSAQA QPQPSSSSRQ RQQQPKSNSH AAIDWGKMAE QWLQEKEAER RKQKQRLTPR PSPSPMIEST PMSIAGDATP LLDEMDR

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1500-1726 of human SUPT6H (NP_003161.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IF,1:50 - 1:200,IP,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu Spt6

Target: Spt6 (SUPT6H) (Suppressor of Ty 6 Homolog (SUPT6H))

Andere Bezeichnung: SUPT6H

Hintergrund: Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD of the RNAPII subunit RPB1 (POLR2A. The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10 as well as histone modifying enzymes (such as SETD2, to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A.,SUPT6H,SPT6,SPT6H,emb-5,SPT6 homolog,Epigenetics & Nuclear Signaling,RNA Binding,Chromatin Remodeling,SUPT6H

Molekulargewicht: 61kDa/84kDa/199kDa

Gen-ID: 6830

UniProt: Q7KZ85

Pathways: Regulation of Leukocyte Mediated Immunity, Regulation of Muscle Cell Differentiation, Production of Molecular Mediator of Immune Response