ARHGAP11B Antikörper (AA 218-267)

Produktnummer ABIN7269963

Der Kaninchen Polyklonal anti-ARHGAP11B Antikörper (ABIN7269963) detektiert spezifisch ARHGAP11B in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für ARHGAP11B Antikörper (AA 218-267) (ABIN7269963)

Target: ARHGAP11B (rho GTPase Activating Protein 11B (ARHGAP11B))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ARHGAP11B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-ARHGAP11B Antikörper

Bindungsspezifität: AA 218-267

Verwendungszweck: ARHGAP11B Rabbit pAb

Sequenz: EKKGVYQTLS WKRYQPCWVL MVSVLLHHWK ALKKVNMKLL VNIREREDNV

Kreuzreaktivität: Human

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 218-267 of human ARHGAP11B (NP_001034930.1).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu ARHGAP11B

Target: ARHGAP11B (rho GTPase Activating Protein 11B (ARHGAP11B))

Andere Bezeichnung: ARHGAP11B

Hintergrund: Hominin-specific protein that promotes development and evolutionary expansion of the brain neocortex. Able to promote amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis, thereby playing a key role in neocortex expansion. Promotes the proliferation of basal progenitors by inhibiting the mitochondrial permeability transition pore (mPTP: delays the opening of the mPTP via interaction with ADP:ATP translocase, thereby increasing mitochondrial Ca(2+ concentration and inducing glutamine catabolism, which is required for basal progenitor proliferation. Does not possess GTPase activator activity: the absence of GTPase activator activity is required to promote amplification of basal progenitors during neocortex development.,ARHGAP11B,FAM7B1,Signal Transduction,G protein signaling,Signal Transduction,ARHGAP11B

Molekulargewicht: 30kDa

Gen-ID: 89839

UniProt: Q3KRB8