PLSCR1 Antikörper

Produktnummer ABIN7269354

Dieses Anti-PLSCR1-Antikörper ist ein Kaninchen Monoklonal-Antikörper zur Detektion von PLSCR1 in WB, IHC und IF. Geeignet für Human.

Kurzübersicht für PLSCR1 Antikörper (ABIN7269354)

Target: PLSCR1 (phospholipid Scramblase 1 (PLSCR1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser PLSCR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-PLSCR1 Antikörper

Verwendungszweck: Phospholipid Scramblase 1 (PLSCR1) Rabbit mAb

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Monoclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: A synthesized peptide derived from human Phospholipid Phospholipid Scramblase 1 (PLSCR1) (PLSCR1)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu PLSCR1

Target: PLSCR1 (phospholipid Scramblase 1 (PLSCR1))

Andere Bezeichnung: PLSCR1

Hintergrund: Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of phospholipids (lipid scrambling or lipid flip-flop between the inner and outer leaflet of the plasma membrane resulting in collapse of the phospholipid asymmetry which leads to phosphatidylserine externalization on the cell surface. Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with TRPC5 (By similarity. Also exhibits magnesium-dependent nuclease activity against double-stranded DNA and RNA but not single-stranded DNA and can enhance DNA decatenation mediated by TOP2A. Negatively regulates FcR-mediated phagocytosis in differentiated macrophages. May contribute to cytokine-regulated cell proliferation and differentiation (By similarity. May play a role in the antiviral response of interferon (IFN by amplifying and enhancing the IFN response through increased expression of select subset of potent antiviral genes. Acts as an attachment receptor for HCV.,MMTRA1B,Calcium Signaling,Cardiovascular,Lipids,Lipids_Lipoproteins/Apolipoproteins,Neuroscience,Signal Transduction,PLSCR1

Molekulargewicht: 35kDa

Gen-ID: 5359

UniProt: O15162

Pathways: Cellular Response to Molecule of Bacterial Origin