Phospholamban Antikörper (pSer16, pThr17)
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- Target Alle Phospholamban (PLN) Antikörper anzeigen
- Phospholamban (PLN)
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Bindungsspezifität
- pSer16, pThr17
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Phospholamban Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Verwendungszweck
- Phospho-PLN-S16/T17 Rabbit pAb
- Kreuzreaktivität
- Human, Maus, Ratte
- Produktmerkmale
- Phosphorylated Antibodies
- Aufreinigung
- Affinity purification
- Immunogen
- A synthetic phosphorylated peptide around of human Phospho-PLN-S16/T17.
- Isotyp
- IgG
- Top Product
- Discover our top product PLN Primärantikörper
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- Applikationshinweise
- WB,1:500 - 1:2000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- Phospholamban (PLN)
- Andere Bezeichnung
- PLN (PLN Produkte)
- Hintergrund
- The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy.,CMD1P,CMH18,PLB,PLN,Cancer,Signal Transduction,Endocrine & Metabolism,Neuroscience,Calcium Signaling,Cardiovascular,Heart,Contractility,PLN
- Molekulargewicht
- 6kDa
- Gen-ID
- 5350
- UniProt
- P26678
- Pathways
- Negative Regulation of Transporter Activity
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