This gene encodes a mitochondrial enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of guanosine triphosphate (GTP). A cytosolic form of this protein is encoded by a different gene and is the key enzyme of gluconeogenesis in the liver. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2014],PEPCK, PEPCK-M, PEPCK2,Cancer,Carbohydrate metabolism,Cardiovascular,Endocrine & Metabolism,Endocrine and metabolic diseases,Endocrine and metabolic diseases_Obesity,Kinase,Lipid Metabolism,Lipid Metabolism_Cholesterol Metabolism,Lipids,Mitochondrial metabolism,Mitochondrial metabolism_Mitochondrial markers,Signal Transduction,PCK2