PAPD5 Antikörper (AA 480-590)

Produktnummer ABIN7269170

Der Kaninchen Polyklonal Anti-PAPD5-Antikörper wurde für WB validiert. Er ist geeignet, PAPD5 in Proben von Human zu detektieren.

Kurzübersicht für PAPD5 Antikörper (AA 480-590) (ABIN7269170)

Target: PAPD5 (PAP Associated Domain Containing 5 (PAPD5))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PAPD5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PAPD5 Antikörper

Bindungsspezifität: AA 480-590

Verwendungszweck: PAPD5 Rabbit pAb

Sequenz: YYPNNETESI LGRIIRVTDE VATYRDWISK QWGLKNRPEP SCNGNGVTLI VDTQQLDKCN NNLSEENEAL GKCRSKTSES LSKHSSNSSS GPVSSSSATQ SSSSDVDSDA T

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Aufreinigung: Affinity purification

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 480-590 of human PAPD5 (NP_001035374.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu PAPD5

Target: PAPD5 (PAP Associated Domain Containing 5 (PAPD5))

Andere Bezeichnung: PAPD5

Hintergrund: Terminal nucleotidyltransferase that catalyzes preferentially the transfert of ATP and GTP on RNA 3' poly(A tail creating a heterogeneous 3' poly(A tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation. Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro. Required for cytoplasmic polyadenylation of mRNAs involved in carbohydrate metabolism, including the glucose transporter SLC2A1/GLUT1. Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion. Mediates 3' adenylation of the microRNA MIR21 followed by its 3'-to-5' trimming by the exoribonuclease PARN leading to degradation. Mediates 3' adenylation of H/ACA box snoRNAs (small nucleolar RNAs followed by its 3'-to-5' trimming by the exoribonuclease PARN which enhances snoRNA stability and maturation.,PAPD5,TRF4-2,Epigenetics & Nuclear Signaling,RNA Binding,Cancer,Drug resistance,Topoisomerases,PAPD5

Molekulargewicht: 41kDa/51kDa/63kDa/64kDa/75kDa

Gen-ID: 64282

UniProt: Q8NDF8