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Nicastrin Antikörper (AA 429-669)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Nicastrin in WB und IF. Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN7268905

Kurzübersicht für Nicastrin Antikörper (AA 429-669) (ABIN7268905)

Target

Alle Nicastrin (NCSTN) Antikörper anzeigen
Nicastrin (NCSTN)

Reaktivität

  • 42
  • 34
  • 24
  • 5
  • 5
  • 5
  • 1
  • 1
  • 1
Human

Wirt

  • 57
  • 3
Kaninchen

Klonalität

  • 48
  • 12
Polyklonal

Konjugat

  • 28
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Nicastrin Antikörper ist unkonjugiert

Applikation

  • 46
  • 13
  • 13
  • 11
  • 10
  • 8
  • 8
  • 7
  • 6
  • 3
  • 2
Western Blotting (WB), Immunofluorescence (IF)
  • Bindungsspezifität

    • 15
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 429-669

    Verwendungszweck

    NCSTN Rabbit pAb

    Sequenz

    RFLRARNISG VVLADHSGAF HNKYYQSIYD TAENINVSYP EWLSPEEDLN FVTDTAKALA DVATVLGRAL YELAGGTNFS DTVQADPQTV TRLLYGFLIK ANNSWFQSIL RQDLRSYLGD GPLQHYIAVS SPTNTTYVVQ YALANLTGTV VNLTREQCQD PSKVPSENKD LYEYSWVQGP LHSNETDRLP RCVRSTARLA RALSPAFELS QWSSTEYSTW TESRWKDIRA RIFLIASKEL E

    Kreuzreaktivität

    Human, Maus, Ratte

    Produktmerkmale

    Polyclonal Antibodies

    Aufreinigung

    Affinity purification

    Immunogen

    Recombinant fusion protein containing a sequence corresponding to amino acids 429-669 of human NCSTN (NP_056146.1).

    Isotyp

    IgG
  • Applikationshinweise

    WB,1:500 - 1:2000,IF,1:50 - 1:200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store at -20°C. Avoid freeze / thaw cycles.
  • Target

    Nicastrin (NCSTN)

    Andere Bezeichnung

    NCSTN

    Hintergrund

    This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease, however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.,NCSTN,ATAG1874,nicastrin,Signal Transduction,ErbB-HER Signaling Pathway,Cell Biology & Developmental Biology,Notch Signaling Pathway,ESC Pluripotency and Differentiation,Neuroscience,Neurodegenerative Diseases,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,Neurodegenerative Diseases Markers,Stem Cells,NCSTN

    Molekulargewicht

    76kDa/78kDa

    Gen-ID

    23385

    UniProt

    Q92542

    Pathways

    Notch Signalweg, Neurotrophin Signalübertragung
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