NCF4 Antikörper (pThr154)

Produktnummer ABIN7268901

Dieses Anti-NCF4-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von NCF4 in WB. Geeignet für Human.

Kurzübersicht für NCF4 Antikörper (pThr154) (ABIN7268901)

Target: NCF4 (Neutrophil Cytosolic Factor 4, 40kDa (NCF4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NCF4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-NCF4 Antikörper

Bindungsspezifität: pThr154

Verwendungszweck: Phospho-NCF4/p40-phox-T154 Rabbit pAb

Kreuzreaktivität: Human

Produktmerkmale: Phosphorylated Antibodies

Aufreinigung: Affinity purification

Immunogen: A synthetic phosphorylated peptide around T154 of human NCF4.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu NCF4

Target: NCF4 (Neutrophil Cytosolic Factor 4, 40kDa (NCF4))

Andere Bezeichnung: NCF4

Hintergrund: The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.,NCF4,CGD3,NCF,P40PHOX,SH3PXD4,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Endocrine & Metabolism,Mitochondrial metabolism,Mitochondrial markers,NCF4

Molekulargewicht: 39kDa

Gen-ID: 4689

UniProt: Q15080